New Lupanes from Alstonia scholaris Reducing Uric Acid Level

Abstract

Twelve lupanes including three new compounds named alstoscholarilups A−C (1–3) were isolated from the leaves of Alstonia scholaris. Their structures were elucidated by spectroscopic analysis and ECD calculation. Structurally, compound 1 with a rare A ring-seco skeleton formed lactone and degraded C-3, while 2 with a 28-nor and 3 with a 29-nor-lupane skeleton supported the phytochemical diversity and novelty of the plant. Pharmacologically, compounds 4, 7, and 10 reduced the serum uric acid (UA) levels of mice significantly.

Key words

Alstonia scholaris - Apocynaceae - reducing UA levels - lupanes

Publication History

Received: 19 June 2023

Accepted after revision: 28 September 2023

Article published online:
19 October 2023

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